Imipramine Oral Uses, Side Effects, Interactions, Pictures, Warnings
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Imipramine Oral Uses, Side Effects, Interactions, Pictures, Warnings

8.22.2017 | Natalie Carter
Imipramine Oral Uses, Side Effects, Interactions, Pictures, Warnings

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Many drugs besides imipramine may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin ), sparfloxacin, among others. Therefore, before using imipramine, report all medications you are currently using to your doctor or pharmacist.

QT prolongation can rarely cause serious (rarely fatal) fast/ irregular heartbeat and other symptoms (such as severe dizziness, fainting ) that need medical attention right away. Imipramine may cause a condition that affects the heart rhythm (QT prolongation).

Check the labels on all your medicines (e.g., cough -and-cold products) because they may contain drowsiness-containing ingredients or decongestants that could increase your heart rate or blood pressure. Ask your pharmacist about the safe use of those products.

Imipramine can help your child control nighttime bed-wetting. Using this medication to treat depression may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living. It is also used with other therapies for the treatment of nighttime bed-wetting (enuresis) in children. This medication is used to treat depression.

Before using this medicine, consult your doctor or pharmacist if you have had: a recent heart attack. This medication should not be used if you have a certain medical condition.

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Symptoms of a serious allergic reaction include: rash, itching /swelling (especially of the face/ tongue /throat), severe dizziness, trouble breathing. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.

When used in children for bed-wetting, imipramine should be taken one hour before bedtime. If your child usually wets the bed early in the night, the drug may be given earlier in separate doses (e.g., one dose in the afternoon and one dose at bedtime ).

l your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat ), severe stomach / abdominal pain, dark urine, yellowing of eyes / skin.

Store the Canadian product in a tightly closed container at room temperature between 35.6-86 degrees F (2-30 degrees C) away from light and moisture.

Some products that may interact with this drug include: anticholinergics (e.g., atropine, belladonna alkaloids, scopolamine, drugs for Parkinson's disease such as benztropine ), certain drugs for high blood pressure (e.g., clonidine, guanadrel, guanethidine, reserpine ), digoxin, disopyramide, thyroid supplements, valproic acid.

Before having surgery, l your doctor or dentist that you are taking this medication.

(See also the Warning section.). Caution is advised when using this drug in children.

This drug may make you dizzy or drowsy or cause blurred vision. Limit alcoholic beverages. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.

If you notice other effects not listed above, contact your doctor or pharmacist. This is not a complete list of possible side effects.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

GENERIC NAME(S): Imipramine Hcl.

Do not take medications containing desipramine while using imipramine. Imipramine is very similar to desipramine.

l your doctor if you smoke or if you have recently stopped smoking. Cigarette smoking decreases blood levels of this medication.

Keep all medicines away from children and pets. Do not store in the bathroom.

Store the US product in a tightly closed container at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.

Consult your doctor or pharmacist if you have any questions. Read the Medication Guide available from your pharmacist.

l the doctor right away if you notice worsening depression /other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed.

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Get medical help right away if you have any very serious side effects, including: chest pain, slow/fast/ irregular heartbeat, fainting, seizures, slurred speech, weakness on one side of the body, eye pain /swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night).

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

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Before taking this medication, l your doctor or pharmacist if you are allergic to it; or to other tricyclic antidepressants (such as desipramine, amitriptyline ); or if you have any other allergies. Talk to your pharmacist for more details. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

See what your medical symptoms could mean, and learn about possible conditions. Drugs & Supplements.

Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Avoid taking MAO inhibitors ( isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine ) during treatment with this medication. Ask your doctor when to start or stop taking this medication. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction.

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Do not share this medication with others.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Infants born to mothers who have taken similar medications during pregnancy may have symptoms such as trouble urinating, prolonged sleepiness, shaking, and seizures.

If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Do not double the dose to catch up. If you miss a dose, take it as soon as you remember.

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The risk of serotonin syndrome/toxicity may be more likely when you start or increase the dose of these drugs. The risk of serotonin syndrome /toxicity increases if you are also taking other drugs that increase serotonin. John's wort, certain antidepressants (including SSRIs such as fluoxetine /paroxetine, SNRIs such as duloxetine / venlaine ), among others. Examples include street drugs such as MDMA/"ecstasy," St.

Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea / vomiting / diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome /toxicity. The risk increases if you are also taking other drugs that increase serotonin, so l your doctor or pharmacist of all the drugs you take (see Drug Interactions section).

Many people using this medication do not have serious side effects. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

This risk may increase if you use certain drugs (such as diuretics /" water pills ") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using imipramine safely. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation.

With WebMD's Medicine Cabinet, you can check interactions with drugs.

Consult your doctor for more details. Laboratory and/or medical tests (e.g., blood counts, EKG, kidney function) may be performed regularly to monitor your progress or check for side effects. Keep all medical appointments.

To decrease dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

Before using this medication, l your doctor or pharmacist your medical history, especially of: breathing problems (e.g., asthma, chronic bronchitis ), personal or family history of glaucoma (angle-closure type), diabetes, eating disorders (e.g., bulimia ), heart problems (e.g., arrhythmias, coronary artery disease ), liver problems, kidney problems, personal or family history of other mental/mood conditions (e.g., bipolar disorder, schizophrenia ), seizures, overactive thyroid ( hyperthyroidism ), trouble urinating (e.g., due to enlarged prostate ), any condition that may increase your risk of seizures (e.g., alcohol/sedative dependency, use of electroconvulsive therapy, brain injury/disease such as stroke ), certain types of tumors (e.g., pheochromocytoma, neuroblastoma ).

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If you have diabetes, this drug may make it harder to control your blood sugar levels. Your anti-diabetic medication or diet may need to be adjusted. l your doctor right away if you have symptoms such as increased thirst/urination, shakiness, unusual sweating, or hunger. Check your blood sugar regularly as directed by your doctor.

In the US.

However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Antidepressant medications are used to treat a variety of conditions, including depression and other mental/ mood disorders. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. These medications can help prevent suicidal thoughts/attempts and provide other important benefits.

Do not take more or less medication or take it more frequently than prescribed. Use this medication regularly in order to get the most benefit from it. Your condition will not improve any faster and your risk of side effects will increase. To help you remember, use it at the same time(s) each day. Follow your doctor's instructions carefully.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. 2016 First Databank, Inc. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.Information last revised December 2016.

Your dose may need to be gradually decreased. It is important to continue taking this medication even if you feel well. Some conditions may become worse when the drug is abruptly stopped. Do not suddenly stop taking this medication without consulting your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast -feeding.

Our pill identification tool will display pictures that you can compare to your pill. Enter the shape, color, or imprint of your prescription or OTC drug.

If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Dry mouth, blurred vision, headache, drowsiness, dizziness, constipation, nausea, vomiting, loss of appetite, diarrhea, stomach cramps, weight gain/loss, and increased sweating may occur.

l your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (e.g., confusion, depression, memory problems), enlarged/painful breasts, unusual breast milk production, irregular/painful menstrual periods, muscle stiffness, restlessness, ringing in the ears, sexual problems (e.g., decreased sexual ability, changes in desire), shakiness (tremors), numbness/tingling of the hands/feet, pain/redness/swelling of arms or legs, trouble urinating.

It works by restoring the balance of certain natural substances (neurotransmitters such as norepinephrine) in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder. Imipramine belongs to a class of medications called tricyclic antidepressants.

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Dizziness, drowsiness, and confusion can increase the risk of falling. Older adults may be more sensitive to the side effects of this drug, especially dizziness (more likely when standing up), drowsiness, constipation, trouble urinating, mental/mood changes (such as confusion, agitation) and heart effects such as QT prolongation (see above).

Since untreated mental/mood problems (such as depression, anxiety, panic disorders ) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediay discuss with your doctor the benefits and risks of using this medication during pregnancy.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Inform your doctor if your condition persists or worsens.

Avoid tanning booths and sunlamps. Limit your time in the sun. Use sunscreen and wear protective clothing when outdoors. l your doctor right away if you get sunburned or have skin blisters /redness. This medication may make you more sensitive to the sun.

You may report side effects to Health Canada at. In Canada - Call your doctor for medical advice about side effects.

Other medications can affect the removal of imipramine from your body, which may affect how imipramine works. Examples include alcohol, barbiturates (such as phenobarbital ), cimetidine, cisapride, haloperidol, certain drugs for heart rhythm (such as flecainide, propafenone), halofantrine, certain HIV protease inhibitors (such as fosamprenavir ), phenothiazines (such as thioridazine), pimozide, certain anti- seizure drugs (such as phenytoin), terbinafine, trazodone, among others.

Take this medication by mouth with or without food, usually 1-4 times daily or as directed by your doctor. In children, dosage may also be based on body weight. Dosage is based on your medical condition and response to therapy. If you have daytime drowsiness, your doctor may direct you to take the entire dose once daily at bedtime. To reduce your risk of side effects, your doctor may start you at a low dose and gradually increase your dose.

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l your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine ), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine ), and narcotic pain relievers (such as codeine, hydrocodone ).

This ed material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use. Selected from data included with permission and ed by First Databank, Inc.

Before using imipramine, l your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems ( heart failure, slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death). The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation.

It may take up to 3 weeks before you experience the full benefits if you are taking this medication for depression. This medication does not work right away.

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When used for an extended period in children for bed-wetting, this medication may not work as well and may require different dosing. Talk with the doctor if this medication stops working well.

Symptoms of overdose may include: severe dizziness, fast/ irregular heartbeat, fainting, hallucinations, seizures. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. US residents can call their local poison control center at. Canada residents can call a provincial poison control center. Otherwise, call a poison control center right away.