10.26.2017 | Ashley Kendal
Diazepam Drug Uses, Dosage & Side Effects
a history of mental illness, depression, or suicidal thoughts or behavior;
Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking this medicine. The sedative effects of diazepam may last longer in older adults.
Alcohol Withdrawal atenolol, Valium, Tenormin, chlordiazepoxide, Librium, clorazepate, More.
new or worsening seizures;
Usual Adult Dose for Alcohol Withdrawal:
depressed mood, thoughts of suicide or hurting yourself;
Keep track of the amount of medicine used from each new bottle. Diazepam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
IM or IV: 2 to 10 mg 2 to 4 times a day as needed. IM: 0.04 to 0.3 mg/kg IM every 2 to 4 hours as needed, up to a maximum of 0.6 mg/kg in 8 hours. 13 to 18 years: Oral: 2 to 10 mg 2 to 4 times a day as needed. Conscious sedation for procedures: Oral: 1 to 12 years: 0.2 to 0.3 mg/kg orally 45 to 60 minutes before procedure, up to a maximum of 10 mg 13 to 18 years: 5 mg orally 45 to 60 minutes before procedure, may repeat with 2.5 mg dose. Sedation: 1 to 12 years: Oral: 0.02 to 0.3 mg/kg every 6 to 8 hours as needed.
Usual Adult Dose for Light Anesthesia:
IV or IM: 5 to 10 mg initially (IV preferred). May be repeated at 10 to 15 minute intervals up to a maximum dose of 30 mg. If necessary, may be repeated again in 2 to 4 hours.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Approval History Calendar Drug history at FDA.
Store at room temperature away from moisture, heat, and light. After you have stopped using this medicine, flush any unused pills down the toilet.
Usual Pediatric Dose for Status Epilepticus:
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Usual Adult Dose for Muscle Spasm:
Usual Pediatric Dose for Seizure Prophylaxis:
See also: Side effects (in more detail).
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Usual Pediatric Dose for Tetanus:
Overdose symptoms may include extreme drowsiness, loss of balance or coordination, limp or weak muscles, or fainting.
Availability Rx Prescription only.
IM or IV: 5 to 10 mg initially, then 5 to 10 mg in 3 to 4 hours, if necessary. For tetanus, larger doses may be required. Oral: 2 to 10 mg 3 to 4 times a day.
Do not stop using diazepam suddenly, or you could have increased seizures or unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
l your doctor about all your current medicines and any you start or stop using, especially: cimetidine; disulfiram (Antabuse); omeprazole; phenytoin;
Diazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peens). It affects chemicals in the brain that may be unbalanced in people with anxiety.
loss of bladder control; or.
provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated June 2nd, 2017), Cerner Multum (updated June 5th, 2017), Wolters Kluwer (updated June 6th, 2017) and others. To view content sources and attributions, please refer to our editorial policy.
Avoid drinking alcohol. Dangerous side effects could occur.
Diazepam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.
asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
a history of drug or alcohol addiction; or.
Maintenance dose: 0.4 to 0.2 mg/kg/hr by continuous IV infusion. Initial dose: 0.02 to 0.08 mg/kg IV over 2 to 5 minutes every 0.5 to 2 hours to control acute agitation.
Diazepam may also be used for purposes not listed in this medication guide.
Usual Pediatric Dose for Light Sedation:
Initiate therapy at first sign of fever and continue for 24 hours after fever resolves. Febrile seizure prophylaxis in children: Oral: 1 mg/kg/day orally in divided doses every 8 hours. IM: 0.04 to 0.3 mg/kg every 2 to 4 hours as needed, up to a maximum of 0.6 mg/kg in 8 hours. 1 to 12 years: Oral: 0.12 to 0.8 mg/kg/day in divided doses every 6 to 8 hours as needed.
kidney or liver disease;
Grapefruit and grapefruit juice may interact with diazepam and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.
Available for Android and iOS devices. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
You should not use this medicine if you are allergic to diazepam or similar medicines (Ativan, Klonopin, Restoril, Xanax, and others), or if you have myasthenia gravis, severe liver disease, narrow-angle glaucoma, a severe breathing problem, or sleep apnea.
Taking diazepam with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
This is not a complete list of side effects and others may occur. You may report side effects to FDA at 1-800-FDA-1088. Call your doctor for medical advice about side effects.
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IM: If IV cannot be used, 5 to 10 mg 30 minutes prior to the procedure. Dosage of narcotics should be reduced by at least a third and in some cases may be omitted. IV: 10 mg or less is usually adequate; however up to 20 mg may be necessary to produce the desired sedation in some patients.
Usual Pediatric Dose for Seizures:
Maximum of 1 episode every 5 days, or 5 episodes per month. Rectal gel: 0.2 mg/kg, rounded up to the nearest available unit dose. May repeat in 4 to 12 hours. Oral: 2 to 10 mg 2 to 4 times a day. A supplemental dose of 2.5 mg may be added for more precise titration or if a portion of the first dose is expelled.
an antibiotic--clarithromycin, erythromycin, ithromycin;
epilepsy or other seizure disorder;
Less than 1 month: 0.83 to 1.67 mg/kg/hour by continuous IV infusion, or 1.67 to 3.33 mg/kg IV, slowly, every 2 hours (20 to 40 mg/kg/day). Greater than 5 years: 5 to 10 mg IM or IV, slowly, repeated every 3 to 4 hours as necessary. Diazepam injection is not recommended as the drug of choice for neonates due to its benzyl alcohol and propylene glycol content. 1 month to 5 years: 1 to 2 mg IM or IV, slowly, repeated every 3 to 4 hours as necessary, or 15 mg/kg/day in divided doses every 2 hours.
an antidepressant such as fluoxetine and others;
Anxiety Xanax, Lexapro, Cymbalta, alprazolam, atenolol, lorazepam, More.
unusual risk-taking behavior, decreased inhibitions, no fear of danger;
Get emergency medical help if you have signs of an allergic reaction to diazepam : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
1 to 12 years: Oral: 0.12 to 0.8 mg/kg/day in divided doses every 6 to 8 hours as needed. IM: 0.04 to 0.3 mg/kg every 2 to 4 hours as needed, up to a maximum of 0.6 mg/kg in 8 hours. Initiate therapy at first sign of fever and continue for 24 hours after fever resolves. Febrile seizure prophylaxis in children: Oral: 1 mg/kg/day orally in divided doses every 8 hours.
Diazepam may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Do not start or stop taking diazepam during pregnancy without your doctor's advice. l your doctor right away if you become pregnant while taking diazepam for seizures.
Seek emergency medical attention or call the Poison Help line at. An overdose of diazepam can be fatal.
You should not breast-feed while using this medicine. Diazepam can pass into breast milk and may harm a nursing baby.
Pregnancy Category D Positive evidence of risk.
Usual Adult Dose for Status Epilepticus:
Do not give this medication to a child younger than 6 months old.
See also: Dosage Information (in more detail).
Usual Adult Dose for Anxiety:
Usual Adult Dose for ICU Agitation:
To make sure diazepam is safe for you, l your doctor if you have any of these conditions: glaucoma;
Usual Pediatric Dose for Muscle Spasm:
Call your doctor at once if you have:
a severe breathing problem;
When treating seizures, do not start or stop taking diazepam during pregnancy without your doctor's advice. Diazepam may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. l your doctor right away if you become pregnant while taking diazepam for seizures.
Misuse of habit-forming medicine can cause addiction, overdose, or death. Diazepam may be habit-forming.
Repeat in 2 to 4 hours if needed. Manufacturer recommendation: Infants greater than 30 days old and Children less than 5 years: IV: 0.2 to 0.5 mg slow IV every 2 to 5 minutes up to a maximum total dose of 5 mg. Repeat in 2 to 4 hours if needed. Infants greater than 30 days old and Children: IV: 0.1 to 0.3 mg/kg dose given over 3 to 5 minutes, every 5 to 10 minutes (maximum of 10 mg/dose). Neonates: IV: (This is not recommended as a first line agent because the injection contains benzoic acid, benzyl alcohol, and sodium benzoate): 0.1 to 0.3 mg/kg/dose given over 3 to 5 minutes, every 15 to 30 minutes to a maximum total dose of 2 mg. Children greater than or equal to 5 years: IV: 1 mg slow IV every 2 to 5 minutes up to a maximum of 10 mg.
Other drugs may interact with diazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. This list is not complete. Not all possible interactions are listed in this medication guide.
l your doctor if you are pregnant or plan to become pregnant. When treating anxiety, alcohol withdrawal, or muscle spasms: If you take diazepam while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.
Diazepam is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.
You should not use this medicine if you are allergic to diazepam or similar drugs (Ativan, Klonopin, Restoril, Xanax, and others), or if you have:
sleep apnea (breathing stops during sleep); or.
1 to 12 years: Oral: 0.12 to 0.8 mg/kg/day in divided doses every 6 to 8 hours as needed. Initiate therapy at first sign of fever and continue for 24 hours after fever resolves. Febrile seizure prophylaxis in children: Oral: 1 mg/kg/day orally in divided doses every 8 hours. IM: 0.04 to 0.3 mg/kg every 2 to 4 hours as needed, up to a maximum of 0.6 mg/kg in 8 hours.
hyperactivity, agitation, aggression, hostility;
little or no urinating.
Generic Name: diazepam (dye AZ e pam) Brand Names: Valium.
alcoholism, or addiction to drugs similar to diazepam.
Call your doctor at once if you feel that this medicine is not working as well as usual, or if you think you need to use more than usual.
Skip the missed dose if it is almost time for your next scheduled dose. Take the missed dose as soon as you remember. Do not take extra medicine to make up the missed dose.
weak or shallow breathing, a feeling like you might pass out; muscle twitching, tremor;
Do not take this medicine for longer than 4 months without your doctor's advice. Diazepam should be used for only a short time.
While using diazepam, you may need frequent blood tests at your doctor's office.
Common diazepam side effects may include: drowsiness; tired feeling; muscle weakness; or loss of coordination.
heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or.
Before you take diazepam, l your doctor if you have glaucoma, asthma or other breathing problems, kidney or liver disease, seizures, or a history of drug or alcohol addiction, mental illness, depression, or suicidal thoughts.
myasthenia gravis (a muscle weakness disorder); severe liver disease;
Usual Pediatric Dose for Anxiety:
Muscle Spasm cyclobenzaprine, Soma, baclofen, tizanidine, Flexeril, Valium, More.
Usual Adult Dose for Endoscopy or Radiology Premedication:
IM or IV: 5 to 10 mg one time. May repeat in 3 to 4 hours, if necessary. Oral: 10 mg 3 to 4 times during the first 24 hours, then 5 mg 3 to 4 times a day as needed.
Diazepam is not approved for use by anyone younger than 6 months old. Do not give this medicine to a child without a doctor's advice.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take diazepam exactly as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results.
if you use a narcotic (opioid) medication.
confusion, hallucinations, unusual thoughts or behavior;
IM or IV: 2 to 5 mg (moderate anxiety) or 5 to 10 mg (severe anxiety) for one dose. Oral: 2 to 10 mg 2 to 4 times a day. May repeat in 3 to 4 hours, if necessary.
A supplemental dose of 2.5 mg may be added in 10 minutes for more precise titration or if a portion of the first dose is expelled. Infants and Children 6 months to 2 years: Dose not established 2 to 5 years: 0.5 mg/kg, rounded up to the nearest available unit dose. May repeat in 4 to 12 hours. Rectal gel: Infants less than 6 months old: Not recommended; product contains benzoic acid, benzyl alcohol, ethanol 10%, propylene glycol, and sodium benzoate. 6 to 11 years: 0.3 mg/kg, rounded up to the nearest available unit dose. 12 years or greater: 0.2 mg/kg, rounded up to the nearest available unit dose. Maximum of 1 episode every 5 days, or 5 episodes per month. Prolonged CNS depression has been reported in neonates receiving diazepam.
CSA Schedule 4 Some potential for abuse.
Usual Adult Dose for Seizures:
HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.
antifungal medicine--itraconazole, ketoconazole, voriconazole;
Other brands: Valium, Diazepam Intensol, Diastat, Diastat AcuDial, Diastat Pediatric.
Premedication for Anesthesia: 10 mg, IM (preferred route), 1 to 2 hours before surgery.
Revision Date:, 10:36:54 AM. Version: 13.04. Cerner Multum, Inc.
Light Sedation promethazine, Valium, Phenergan, Demerol, chlorpromazine, midazolam, More.Diazepam