Flumazenil
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Flumazenil



Romazicon (Flumazenil) Side Effects, Interactions, Warning

9.23.2017 | Victoria Lawman
Flumazenil
Romazicon (Flumazenil) Side Effects, Interactions, Warning

Flumazenil is a white to off-white crystalline compound with an octanol: buffer partition coefficient of 14 to 1 at pH 7.4. It is insoluble in water but.

The pharmacokinetics of benzodiazepines are unaltered in the presence of flumazenil and vice versa.

Routine care should be taken to avoid aerosol generation when preparing syringes for injection, and spilled medication should be rinsed from the skin with cool water. Flumazenil injection is supplied in sealed dosage forms and poses no known risk to the healthcare provider.

The safety and efficacy of repeated flumazenil administration in pediatric patients experiencing resedation have not been established.

Flumazenil

11.25.2017 | Natalie Carter
Flumazenil
Flumazenil

Flumazenil is a selective benzodiazepine receptor antagonist available by injection and intranasal. It has antagonistic and antidote properties to therapeutically.

Radiolabeled with the radioactive isotope carbon-11 flumazenil may be used as a radioligand in neuroimaging with positron emission tomography to visualize the distribution of GABA A receptors in the human brain.

Flumazenil does not antagonize all of the central nervous system effects of drugs affecting GABA-ergic neurons by means other than the benzodiazepine receptor (including ethanol, barbiturates, or general anesthetics) and does not reverse the effects of opioids.

Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures.

Additionally, relapse rates were much less during subsequent follow-up.

Flumazenil Indications, Side Effects, Warnings

12.26.2017 | Nicholas Babcock
Flumazenil
Flumazenil Indications, Side Effects, Warnings

Easy to read patient leaflet for flumazenil. Includes indications, proper use, special instructions, precautions, and possible side effects.

Generic Name: flumazenil (FLOO-may-ze-nil) Brand Name: Romazicon.

Some medical conditions may interact with flumazenil. l your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:.

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Reversing drowsiness, sedation, and other effects caused by benzodiazepines.

Symptoms may include agitation; anxiety; emotional or mood changes; increased sensitivity to pain or touch; seizures.

Flumazenil a new benzodiazepine antagonist

6.20.2017 | John Addington
Flumazenil
Flumazenil a new benzodiazepine antagonist

Flumazenil is a recently discovered pharmacologic antagonist of the CNS effects of benzodiazepines. It acts by binding CNS benzodiazepine receptors and.

more. Warning: The NCBI web site requires JavaScript to function.

National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA. National Center for Biotechnology Information, U.S.

Further studies will continue to define the ultimate use of this new agent. This might be particularly useful because there is nothing about benzodiazepine-induced coma that clearly distinguishes it from other causes of coma; thus, there are no signs or symptoms that may reasonably allow benzodiazepine overdose to be confirmed or eliminated on clinical grounds.

Flumazenil a benzodiazepine antagonist

7.21.2017 | Victoria Lawman
Flumazenil
Flumazenil a benzodiazepine antagonist

The mechanism of action, pharmacokinetics, and use of flumazenil in benzodiazepine overdose, as well as in the management of other disease states, are.

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

Warning: The NCBI web site requires JavaScript to function. more.

It may be beneficial after surgery when benzodiazepines have been used as part of anesthesia and after a diagnostic or surgical procedure when assessment of CNS function is necessary. Flumazenil has been studied for a variety of indications, including as an antidote to benzodiazepine overdose and for awakening of comatose patients, reversal of sedation after surgery and in critically ill patients, and management of hepatic encephalopathy.