Nordiazepam in urine
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Nordiazepam in urine



Urinary Diazepam Metabolite Distribution in a Chronic Pain Population

6.11.2017 | Ashley Kendal
Nordiazepam in urine
Urinary Diazepam Metabolite Distribution in a Chronic Pain Population

Sex, but not age or urinary pH, had an effect on metabolite fractions. Methadone significantly increased temazepam and oxazepam urinary.

Urinary pH and the fraction of diazepam metabolite also demonstrated no statistically significant association. Age was not related to metabolite concentrations for any of the diazepam metabolites. each metabolite fraction demonstrated no relationship. Semi-logarithmic scatterplots of the total excreted moles of diazepam metabolites vs. A linear fit for each metabolite fraction showed that slopes were close to zero and R 2 < 0.15.

Fractions of diazepam metabolites in urine by groups.

The log distribution of the fraction of nordiazepam, temazepam and oxazepam from 22,509 specimens from unique subjects approximated a Gaussian distribution (Figure 2 ).

Urinary diazepam metabolite distribution in a chronic pain population

7.12.2017 | Ashley Kendal
Nordiazepam in urine

Sex, but not age or urinary pH, had an effect on metabolite fractions. Methadone significantly increased temazepam and oxazepam urinary.

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National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA. National Center for Biotechnology Information, U.S.

Intersubject nordiazepam, temazepam and oxazepam geometric mean fractions were 0.16, 0.34 and 0.47, respectively. Sex, but not age or urinary pH, had an effect on metabolite fractions. Although more studies are needed, these results suggest the viability of UDT for increased monitoring for therapy and possible drug-drug interactions. Intrasubject geometric mean fractions were 0.157, 0.311 and 0.494, respectively. Methadone significantly increased temazepam and oxazepam urinary fractions via CYP3A4 inhibition, whereas fluoxetine and esomeprazole increased nordiazepam fractions via CYP2C19 inhibition. Diazepam is often used as an adjuvant to pain therapy. Cytochrome P450 (CYP) 3A4 and 2C19 metabolize diazepam into the active metabolites: nordiazepam, temazepam and oxazepam. This was a retrospective data analysis that evaluated urine specimens from pain management practices for the distribution of diazepam metabolites with and without CYP 3A4 and 2C19 inhibitors. Owing to diazepam's side-effect profile, mortality risk and potential for drug-drug interactions with CYP 3A4 and/or CYP 2C19 inhibitors, urine drug testing (UDT) could be a helpful monitoring tool.

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The urinary elimination profiles of diazepam and its - NCBI

8.13.2017 | Natalie Carter
Nordiazepam in urine

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National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA.

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Diazepam is extensively metabolized in the horse to nordiazepam, temazepam, and oxazepam. Oxazepam and temazepam were not detected in postadministration serum. Valium, a formulation of diazepam, was administered at a dose of 10 mg intramuscularly to four standard-bred mares. Oxazepam and temazepam were entirely conjugated, and their urinary concentrations were measured out to collection times of 121 h and 77-79 h, respectively. Diazepam and nordiazepam were measured in equine postadministration serum out to collection times of 6 and 54 h, respectively. Nordiazepam was found to be mainly in its glucuronide-conjugated form and was measured out to a collection time of 53-55 h. A method for the extraction of diazepam and its metabolites (nordiazepam, temazepam, and oxazepam) from equine urine and serum and their quantitation and confirmation by liquid chromatography-tandem mass spectrometry is presented. Diazepam urinary concentrations were found to be less than 6 ng/mL.

Benzodiazepines, urine (94284R)

11.16.2017 | Ashley Kendal
Nordiazepam in urine

Benzodiazepines, urine Test Code 94284R CPT Code(s) 80346 (HCPCS: G0480) Preferred , NORDIAZEPAM, URINE, 3861-2, Nordiazepam.

Result Code Result Name LOINC Code Component Name OXAZEPAM, URINE 12361-2 Oxazepam NORDIAZEPAM, URINE 3861-2 Nordiazepam ALPHA-HYDROXYALPRAZOLAM,UR 19326-8 Alpha hydroxyalprazolam.

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763910 Benzodiazepine and Metabolite Confirmation LabCorp

3.8.2017 | Natalie Carter
Nordiazepam in urine

Alprazolam; clonazepam; flurazepam; lorazepam; midazolam; nordiazepam; 763910, Benzodiazepines Confirm, Urine, 763906, Nordiazepam Confirm, ng/mL.

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