Synthesis of chlorpromazine
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Synthesis of chlorpromazine



Chlorpromazine hydrochloride synthesis process

8.21.2017 | Natalie Carter
Synthesis of chlorpromazine
Chlorpromazine hydrochloride synthesis process

2013年11月6日 The present invention relates to a method of synthesis of chlorpromazine hydrochloride, 2-chloro-phenothiazine main ring and side chain N.

5)甲苯层分水,搅拌加盐酸酸化至PH2-3,停止搅拌,静置,分去甲苯层,回收甲苯; 5) The toluene layer trap, hydrochloric acid added with stirring to PH2-3, stirring was stopped, allowed to stand, points to the toluene layer was recovered toluene;

4)分去碱水层后,油层用50_60°C热水洗涤,分去水层; After the 4) points to the basic aqueous layer, reservoir 50_60 ° C washed with hot water to the water layer;

加成反应时需要控制好氯丙嗪与异丙醇、浓硫酸、盐酸的质量比,严格控制好溴甲酚蓝指示剂的终点,使产品更加质量稳定。 The need to control the addition reaction when chlorpromazine and isopropanol, concentrated sulfuric acid, hydrochloric acid mass ratio, and strictly control the end of a good indicator of bromocresol blue, make the product more stable quality.

吩噻嗪类的代表药,为中枢多巴胺受体的阻断剂,具有多种药理活性,如治疗精神病、镇吐、顽固性呃逆、低温麻醉及人工冬眠、心力衰竭。 phenothiazines representative drugs for central dopamine receptor antagonist, has a variety of pharmacological activities, such as the treatment of mental illness, antiemetic, intractable hiccups, hypothermic anesthesia and artificial hibernation, heart failure.

Synthesis and synergistic antimycobacterial

7.20.2017 | Kaitlyn Leapman
Synthesis of chlorpromazine
Synthesis and synergistic antimycobacterial

The antimycobacterial activities of chlorpromazine and its metabolites were evaluated alone and in combination with antitubercular drugs. Although associated.

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The article was received on 17 Dec 2013, accepted on 28 Jan 2014 and first published on 05 Mar 2014.

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Synthesis of N13CH3 drugs (chlorpromazine, triflupromazine and

3.16.2017 | John Addington
Synthesis of chlorpromazine

Abstract. These [N-13CH3] containing drugs (chlorpromazine, triflupromazine and promazine) have been synthesized by means of a two-step.

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These containing drugs (chlorpromazine, triflupromazine and promazine) have been synthesized by means of a two-step demethylation/methylation procedure. 2000 John Wiley & Sons, Ltd.

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Synthesis of deuteriumlabelled chlorpromazine and

6.19.2017 | Ashley Kendal
Synthesis of chlorpromazine

Synthesis of deuterium‐labelled chlorpromazine and chlorpromazine metabolites on ResearchGate, the professional network for scientists.

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Chlorpromazine 50-53-3 Route Of Synthesis Synthetic Routes

12.25.2017 | Ashley Kendal
Synthesis of chlorpromazine

Chlorpromazine 50-53-3 route of synthesis, chlorpromazine chemical synthesis methods, chlorpromazine synthetic routes ect.